Challenges of a Large Pragmatic Trial: the ALLHAT Experience

June 28, 2018
4:30 p.m. - 6 p.m.
Taylor Ave Bldng, Rm 2131, Medical Campus

The Division of Public Health Sciences, Department of Surgery, invites you to the next Epidemiology and Clinical Outcomes Research Seminar Series talk on Thursday, June 28, 2018 at 4:30 p.m. Join us as Barry R. Davis, MD, PhD, the Guy S. Parcel Chair in Public Health, Professor of Biostatistics, and Director of the Coordinating Center for Clinical Trials at The University of Texas School of Public Health presents “Challenges of a Large Pragmatic Trial: the ALLHAT Experience.

This event will be held in the Doll & Hill Teaching Room 2131 in the Taylor Avenue Building (600 S. Taylor). No RSVP needed; open to all. Learn more about this seminar series at

More information:
Major clinical trial and statistical challenges will be presented from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) trial. This data set was a large (n=42,418), pragmatic, randomized, double-blind, active-controlled hypertension treatment trial designed to compare a calcium channel blocker (amlodipine), an ACE-inhibitor (lisinopril), or an α-blocker (doxazosin), each compared to a diuretic (chlorthalidone), in reducing risk of coronary heart disease. ALLHAT enrolled a broadly representative patient population from 623 clinics. It was conducted in typical health care settings, used broad inclusion criteria, and was minimally intrusive on routine clinical practice.

For more information, contact: Katy Henke, or 314-454-7650.

Event Sponsors: Division of Public Health Sciences, Department of Surgery, Institute for Public Health, the Department of Obstetrics and Gynecology, the Department of Medicine, and the Department of Anesthesiology