investigatorS: Mark D. Huffman, MD, MPH; JODY D.CIOLINO, PhD

QUARTET USA is a phase II randomized trial testing the effect of a four-drug, quarter-dose blood pressure lowering combination among individuals with hypertension in federally qualified health centers in Chicago as part of the global QUARTET program (trial ongoing in Australia and in development in The Netherlands and Japan). This trial represents a reverse innovation of using fixed-dose combination, or polypill, therapy for cardiovascular disease prevention within a U.S. population that bears one of the highest burdens of hypertension-related illness in the world.


National Heart, Lung, and Blood Institute (R61 HL139852)

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